Acne doxycycline is an α-6-deoxy-5-oxytetracycline. This is a semi-synthetic structural isomer of tetracycline, which has a broad spectrum of Gram positive and negative, and intracellular bacteria and also on the Plasmodium.
Acne doxycycline is a bacteriostatic intracellular ribosome. But are also susceptible Gram-positive aerobic bacteria and anaerobic bacteria and rickettsia, chlamydia and spirochetes.
Acne doxycycline is also active on Gram-negative aerobic bacteria such as Haemophilus influenzae, Neisseria, Brucella, Bacillus anthracis, but are certain to have an intrinsic resistance is the example of Acinetobacter, Pseudomonas and Proteus.
Resistance mechanisms are acquired and related to impaired intracellular target (ie the ribosome), or related to inhibition of absorption of the antibiotic by changing the structure of the cell membrane (called: resistance plasmid ).
Example:
A porin deficient is the cause of resistance in Gram-negative bacteria.
Doxycycline possèede also antiparasitic activity of Plasmodium. For inhibits parasite mitochondrial protein synthesis.
Note: cyclins also have anti-inflammatory, used to advantage in certain dermatological diseases
Doxycycline is indicated for the treatment of acne: 100 mg / day is used in acne papulopustular facial predominantly non-scarring. While the association is against retinoid-indicated because it can lead to intracranial hypertension.
The main antibiotics used in oral acne are tetracycline (300 to 600 mg / day), doxycycline and minocycline (100 to 200 mg / d). These antibiotics exert an antibacterial effect against bacterium acnes propionic and an anti-inflammatory effect.
NB:
encountered side effects with minocycline, so they must be taken into account (such liver damage and reactions lupus with arthralgia during prolonged treatment ..).
Doxycycline is associated with a significant risk of phototoxicity, tetracycline and es-cons are given during pregnancy.
The effectiveness of doxycycline (or other antibiotics, unwanted in the treatment of acne) should be evaluated after three months if there is an improvement, the antibiotic can be extended to six months, but always in combination with a Local treatment with benzoyl peroxide or a retinoid.
By cons, in the absence of efficacy after 3 months, antibiotic therapy should be discontinued and another treatment should be considered.
Acne doxycycline is a bacteriostatic intracellular ribosome. But are also susceptible Gram-positive aerobic bacteria and anaerobic bacteria and rickettsia, chlamydia and spirochetes.
Acne doxycycline is also active on Gram-negative aerobic bacteria such as Haemophilus influenzae, Neisseria, Brucella, Bacillus anthracis, but are certain to have an intrinsic resistance is the example of Acinetobacter, Pseudomonas and Proteus.
Resistance mechanisms are acquired and related to impaired intracellular target (ie the ribosome), or related to inhibition of absorption of the antibiotic by changing the structure of the cell membrane (called: resistance plasmid ).
Example:
A porin deficient is the cause of resistance in Gram-negative bacteria.
Doxycycline possèede also antiparasitic activity of Plasmodium. For inhibits parasite mitochondrial protein synthesis.
Note: cyclins also have anti-inflammatory, used to advantage in certain dermatological diseases
Doxycycline is indicated for the treatment of acne: 100 mg / day is used in acne papulopustular facial predominantly non-scarring. While the association is against retinoid-indicated because it can lead to intracranial hypertension.
The main antibiotics used in oral acne are tetracycline (300 to 600 mg / day), doxycycline and minocycline (100 to 200 mg / d). These antibiotics exert an antibacterial effect against bacterium acnes propionic and an anti-inflammatory effect.
NB:
encountered side effects with minocycline, so they must be taken into account (such liver damage and reactions lupus with arthralgia during prolonged treatment ..).
Doxycycline is associated with a significant risk of phototoxicity, tetracycline and es-cons are given during pregnancy.
The effectiveness of doxycycline (or other antibiotics, unwanted in the treatment of acne) should be evaluated after three months if there is an improvement, the antibiotic can be extended to six months, but always in combination with a Local treatment with benzoyl peroxide or a retinoid.
By cons, in the absence of efficacy after 3 months, antibiotic therapy should be discontinued and another treatment should be considered.
